Postdoctoral Research Fellows (m/f/div)(job code 02-2021)
The Antebi Department for ‘Molecular Genetics of Ageing’ investigates how regulatory networks govern animal health and life span. We primarily use the roundworm Caenorhabditis elegans and the turquoise killifish Nothobranchius furzeri as model organisms, as well as cell culture and mouse. The overarching goals are to reveal conserved, convergent mechanisms of longevity, and to understand how immunity, metabolism, and quality control mechanisms cooperate in cellular defense. We apply a multidisciplinary approach combining genetics, systems biology, cell and molecular biology, imaging, biochemistry, and mass spectrometry in order to understand the biology of ageing and age-related disease. In particular, we have a long-standing interest in understanding how naturally occurring metabolites can serve as signalling molecules that regulate animal health and life span, and we are using metabolomic approaches to identify such factors. We seek a highly motivated and talented scientist to join our enthusiastic, collaborative, and diverse team in an outstanding scientific environment to take part in our exciting research. The successful applicant will hold a Ph.D. in a relevant research area such as molecular biology, genetics, biochemistry, or metabolomics and has a strong track record of accomplishment. Prior experience with model organisms (worm, fly, mouse) would be welcome, but is not required. The applicant should have a keen interest in the biology of ageing and excellent written and oral communication skills. The working language is English; knowledge of German is not required. The Max Planck Institute for Biology of Ageing, Cologne, was founded in 2008 with the aim to understand fundamental mechanisms of healthy ageing in various model systems. The institute is part of a network of research institutions in the Cologne-Bonn area dedicated to research on ageing and age-related disease, constituting a vibrant and collaborative environment. Equipped with state-of-the-art technology and excellent core facilities, to which the successful candidate will have access, the institute provides outstanding research opportunities for its scientists. At the moment, we host employees from more than 30 different nations worldwide. The employment contract will be based on contracts for the civil service (TVöD Bund, Tarifvertrag für den öffentlichen Dienst) and will initially be time-limited. The Max Planck Society is committed to employ more disabled individuals and especially encourages them to apply. We also seek to increase the number of women in those areas where they are underrepresented and particularly encourage them to apply. Then please upload your complete application documents, containing a one-page letter with a personal statement describing your scientific accomplishments and your interests in our laboratory, your CV and bibliography, as well as contact information for three references, in electronic form as one single PDF file via our online application platform. Applications will be evaluated on a rolling basis until the position is filled. Informal inquiries are welcome and should be sent to recruitment-AA@age.mpg.de. For further information about the Institute and the Antebi department please see www.age.mpg.de. Please do consult recent publications from the Antebi department for more information on our scientific projects: Annibal, A., Tharyan, R.G., Schonewolff, M.F., Tam, H., Latza, C., Auler, M.M.K., Gronke, S., Partridge, L., Antebi, A. (2021) Regulation by the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun 12: 3486 Tharyan, R.G., Annibal, A., Schiffer, I., Laboy, R., Atanassov, I., Weber, A.L., Gerisch, B., Antebi, A. (2020) NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Nat Metab 2: 387-396 Kew, C., Huang, W., Fischer, J., Ganesan, R., Robinson, N., Antebi, A. (2020) Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60. Elife 9: e57591 Gerisch, B., Tharyan, R.G., Mak, J., Denzel, S.I., Popkes-van Oepen, T., Henn, N., Antebi, A. (2020) HLH-30/TFEB is a Master Regulator of reproductive quiescence. Dev Cell 53: 316-329 Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Späth, M., Suchiman, H., Eka, D., Müller, R.U., Slagboom, P.E., Partridge, L., and Antebi, A. (2017) Small nucleoli are a cellular hallmark of longevity. Nat Commun 8: 16083.
https://www.nature.com/naturecareers/job/postdoctoral-research-fellows-mfdiv-max-planck-institute-for-biology-of-ageing-mpiage-747739
