Area of research: PHD Thesis Job description: Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world. At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution for a healthier society. Are you passionate about science, full of ideas and innovative potential that drive change and enjoy working in an international, fast-paced environment? Are you motivated by the societal impact of research and seek an opportunity to play an instrumental part in the development of emerging technologies for biology, healthcare and environmental applications? Then the (IBMI) at the Helmholtz Zentrum Muenchen (HMGU) and its integrated Chair of Biological Imaging (CBI) at the Technical University of Munich (TUM), Germany, is the ideal environment for you! IBMI is the cornerstone of a rapidly expanding bioengineering ecosystem in the Munich science area; including the and the , which integrate bioengineering with metabolic disorders and oncology, respectively. IBMI scientists develop next-generation imaging and sensing methods to measure previously inaccessible properties of living systems, hence, catalyzing breakthroughs in biology, medicine and the environment. Comprising 11 inter-disciplinary laboratories and scientists from more than 25 countries, IBMI offers state-of-the-art infrastructure for innovative research and a perfect environment to accelerate your career. Our research aims to shift the paradigm of biological discovery and translation to address major health challenges of our time and develop the medical solutions of tomorrow. Join our team and be part of our rich and dynamic research culture of enquiry and innovation. IBMI researchers come from the top ranks of physics, engineering, chemistry, biomedicine and computer science and our pipeline frequently yields high-impact papers, successful technology spin-offs and commercialization. Our research is regularly featured in major news channels and has received broad recognition including several prestigious awards and considerable research funding from national and international sources. At IBMI we are now looking for a highly qualified and passionate PhD student in protein engineering: focus on development of imaging labels and sensors (f/m/d). Full time Neuherberg near Munich PhD Your mission Genetically encoded sensors are a major tool to unravel the functioning of life on the cellular level. We seek to expand this by visualizing molecular processes on the tissue level with high resolution. The mission is to develop dedicated genetically encoded sensors for optoacoustics measurements. The candidate will focus on engineering chimeric proteins that show a small-molecule binding dependent change of photophysics. One of our main foci for readout are photo-switching proteins. Here the candidate will further explore and exploit their intricate and exciting mechanisms towards driving such proteins towards a use in applications. The workflow will span from protein-engineering and high-throughput screening over photo-physical and structural characterization to mammalian cell culture and eventual in vivo application. The work will be conducted in close collaboration with other laboratories of TUM and HMGU that are leading in the respective research areas, e.g. in vivo application or protein structure elucidation. Hence, the position is an exciting interface between protein-engineering, basic photophysical research, development of molecular tools as well as imaging. Your qualifications
High motivation, curiosity, and commitment to scientific excellence Master Degree in Chemistry, Physics, Biochemistry or similar field Background in chromophores, photophysics, photochemistry Experience in protein engineering Experience in high-throughput screening Interest in excited state photophysics, and photoisomerization processed will be appreciated as well as understanding of (protein-) environmental effects on the photophysical properties of chromophores Interest in optical spectroscopy techniques Interest in imaging Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment Excellent command of the English language What we offer you scientific training at Graduate School work-life balance flexible working hours 30 days annual leave on-site health management service career consultation home office options on-site nursery company pension scheme discounted public transport ticket Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.
https://www.nature.com/naturecareers/job/phd-student-in-protein-engineering-fmx-helmholtz-zentrum-munchen-german-research-center-for-environmental-health-hmgu-745806
