Though it’s already publicly traded in the US and Hong Kong, BeiGene went and triple-listed itself in Shanghai’s stock exchange as well. But early returns have reportedly been far from promising.
BeiGene shares in Shanghai fell more than 16% after debuting Wednesday, following a $3.5 billion raise for the biotech. It had been the year’s biggest IPO on the Shanghai stock exchange, known as STAR, as well as the largest IPO offering by any Chinese healthcare firm in at least the last two decades, according to the report.
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Sensor-based technology for clinical trial data collection represents the latest medical paradigm shift. There are more than 700 clinical studies involving wearable devices currently underway in the United States. A study from Intel IT projects their inclusion in clinical trials will surge to 70% by 2025.
Apps, biosensors and patient-centered technologies increase visibility of comprehensive patient data. Pharma leaders anticipate the benefits of wearables to include better data (58%), faster results (33%) and lower trial costs (10%).
A nurse administers a COVID-19 booster shot to Joe Rigdon at a vaccination site in Eastmonte Park, Altamonte Springs. (Photo by Paul Hennessy/SOPA Images/LightRocket via Getty Images)
When Laura Burns went to get her first Covid-19 shot last January, no one had warned her that the vaccines might not work for her.
Burns, the recipient of a double-lung transplant in 2016, knew to be careful about the medicines she took. She consulted with her transplant team when the Pfizer and Moderna shots were authorized and only signed up after being told the vaccines would likely be safe for her, which they were.
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Jay Bradner, President, Novartis Institutes for BioMedical Research
John Carroll: Well, hello everybody. This is John Carroll. I’m the editor of Endpoints News, the editor and founder of Endpoints News. I’m here with Jay Bradner, the president of the Novartis Institutes for BioMedical Research. Jay, we’re going to be talking about ASH in just a second, but you’ve just recently celebrated your sixth anniversary as president of NIBR. And I’m curious, it’s such a significant amount of time for anybody to spend in one career phase. And looking back over the last six years, is everything fundamentally different about the research process and the translational arena that you’re in?
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Albert Bourla (Evan Vucci, AP Images)
After a post-marketing trial for Pfizer’s Xeljanz turned concerning safety results at the beginning of the year, thwarting the whole JAK class, the FDA is finally rolling out some new approvals — but with added warnings and a key label change.
Both Xeljanz and AbbVie’s Rinvoq got cleared for new indications on Tuesday, but on one condition: They can only be taken after a patient has failed on one or more tumor necrosis factor (TNF) blockers, like Humira or Enbrel.
We will now have to wait until 2022 to find out whether Sanofi and GlaxoSmithKline have an effective recombinant vaccine against Covid-19.
The two pharma giants revealed that their Phase III trial isn’t quite ready for a readout. Meanwhile, they seem to have more hope in the booster application of their candidate, touting positive preliminary data suggesting that it spurred an increase in neutralizing antibodies in all patients — whether they received mRNA or adenovirus-based shots as the primary vaccines.
Harpreet Singh, Immatics CEO (Credit: Allogeneic Cell Therapies Summit)
Just a few weeks after offering a positive readout on its first early clinical-stage offering, the transatlantic biotech Immatics is back with news that the research crowd around Rupert Vessey at Bristol Myers Squibb has anted up $150 million in cash to get on at the ground floor with one of their still-preclinical efforts.
This time the news is centered on IMA401, Immatics’ most advanced bispecific, which uses one binder to latch on to MAGEA4/8 while another is used to whip up T cell activity against tumor cells where that’s a common antigen. For now, that’s still a preclinical effort, with the first human trial set to launch in the first half of next year.
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CVS Health is adding clinical trial services inside some of its retail locations with HealthHubs and in the future at CVS primary care centers (via CVS Health)
During the Covid-19 pandemic, local pharmacies were not only key purveyors of prescriptions and hand sanitizer, but also important testing and vaccine delivery locations. Next up? Clinical trial sites. That’s according to a recent PwC Health report that lays out the case for both pharma and pharmacies — and why it’s more probable than ever.
Figuring out how to scale decentralized trials is necessary, made clear by the pandemic, said Greg Rotz, PwC’s pharma and life sciences leader in the US. The good news from his perspective is both pharma companies and retailers are investing in business models and infrastructure to make it happen.
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Robert Califf (L) shakes hands with Sen. Mitt Romney (R-UT) at Califf’s confirmation hearing for FDA commissioner, Dec. 14, 2021 (Graeme Sloan/Sipa via AP Images)
Rob Califf, the famous cardiologist from Duke University, is likely to return to the top of the FDA, this time under the Biden administration.
At his confirmation hearing Tuesday, Democrats and Republicans on the Senate health committee offered their support for Califf, with Chair Patty Murray (D-WA) stressing the need for an experienced leader, like Califf, who can ensure that science comes first.
A Boston-based provider of lab space is tripling its footprint with the addition of a West Coast campus.
SmartLabs, a company with labs in three different neighborhoods in the Boston area, will open a new research and manufacturing center that will be located in the heart of the South San Francisco biotech corridor. The site will support end-to-end drug development and include 500L manufacturing bioreactors that can support allogeneic and autologous cell therapies.
https://endpts.com/beigene-slides-on-shanghai-debut-as-us-preps-to-blacklist-some-chinese-biotechs/
