A fledgling transpacific biotech grabs a launch round to dive into oncology and autoimmune research

Peter Ding, Allorion Therapeutics co-founder and CEO

Pre­ci­sion-med biotech Al­lo­ri­on Ther­a­peu­tics is ex­pand­ing — and now has tens of mil­lions of dol­lars more to work with.

The Nat­ick, MA-based com­pa­ny an­nounced in a state­ment this morn­ing that it closed a Se­ries A round, bring­ing in $40 mil­lion.  Shang­hai VC Qim­ing Ven­ture Part­ners led the round, which al­so in­cludes a num­ber of both new and old in­vestors — Oc­ta­gon Cap­i­tal, IDG Cap­i­tal and TF Cap­i­tal, to name a few.

Ac­cord­ing to Al­lo­ri­on, which has op­er­a­tions in both Mass­a­chu­setts and Guangzhou, Chi­na, the $40 mil­lion will go to­ward pre­clin­i­cal projects, IND-en­abling stud­ies and IND ap­pli­ca­tions of two drug can­di­dates in Chi­na and the US. It al­so in­cludes in­vest­ing in its own in­ter­nal drug dis­cov­ery plat­form.

The biotech fo­cus­es on dis­cov­er­ing small mol­e­cules specif­i­cal­ly against can­cer and au­toim­mune dis­eases — but to what ex­tent re­mains un­clear. Al­lo­ri­on has not yet named any tar­gets or pro­grams it is pri­or­i­tiz­ing.

How­ev­er, the com­pa­ny says there is an in­ter­nal fo­cus on ‘chem­i­cal li­braries,’ em­pha­siz­ing al­losteric and co­va­lent mod­u­la­tors, with a hint of AI through ‘op­ti­miz­ing the li­braries through the aid of AI.’

Al­lo­ri­on start­ed up close to 18 months ago in June 2020, when co-founders Pe­ter Ding and Fang Li got to­geth­er. Ding, cur­rent­ly Al­lo­ri­on’s CEO, came over from an­oth­er com­pa­ny where he was a co-founder — Cure­genix, where he was al­so head of R&D. Li joined up as CSO af­ter leav­ing his po­si­tion as the head of trans­la­tion­al and com­pu­ta­tion­al bi­ol­o­gy at Cam­bridge pre­ci­sion on­col­o­gy play­er Tan­go Ther­a­peu­tics.

And last De­cem­ber, Al­lo­ri­on got their in­ter­nal labs up and run­ning at their sites in MA and Guangzhou, ac­cord­ing to a com­pa­ny state­ment.

‘We have con­fi­dence in the team’s strong R&D ca­pa­bil­i­ties. We hope to sup­port Al­lo­ri­on to grow in­to a glob­al­ly-rec­og­nized com­pa­ny and im­prove pa­tients’ life qual­i­ty,’ Ding said in a pre­pared state­ment.

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Joan Perelló, Sanifit CEO

Joan Perelló beat all the odds with his little Spanish biotech startup Sanifit.

Working on the far perimeter of the big US/European drug development scene, he took a drug born out of his PhD work and got enough seed cash to get started. That’s one near miracle. In the second near miracle he gathered a previously unheard of venture raise in Spain — helping build an industry ecosystem from scratch — to pursue a successful search for solid human data for his drug, SNF472. And while gathering a virtual team of developers from Europe and the US, the CEO/co-founder steered it into the late-stage arena.

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Pascal Soriot, AstraZeneca CEO (Chris Ratcliffe/Bloomberg via Getty Images)

While Europe is in the midst of a massive fourth Covid-19 surge, the UK has largely avoided the high levels of hospitalizations and deaths seen on the rest of the continent. And AstraZeneca CEO Pascal Soriot suggested Tuesday the reason for Britain’s better fortunes could be his company’s vaccine.

In a one-on-one interview with BBC Radio 4, a reporter asked Soriot whether he was disappointed over the UK’s decision not to use the AstraZeneca/Oxford shot as a booster. Soriot responded by touting the vaccine’s T cell response, saying some data have shown it may be more durable than mRNA shots in older people, where the focus had largely been on antibodies.

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Emma Walmsley, GlaxoSmithKline CEO (Fang Zhe/Xinhua/Alamy Live News)

As activist investors champ at the bit for change at drug giant GlaxoSmithKline, the pharma giant has turned over many rocks to find an R&D success to present to its detractors. In NASH, a field strewn with failures, GSK hopes a new license deal can churn out a much-needed winner.

GSK will pay $120 million in upfront cash and $910 million in downstream milestones to develop and sell ARO-HSD, Arrowhead Pharmaceuticals’ RNA interference drug targeting fatty liver disease nonalcoholic steatohepatitis (NASH), the companies said Monday.

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Most people know if they’re ‘Team Pfizer’ or ‘Team Moderna,’ but few know if they got the Comirnaty or Spikevax Covid-19 vaccine. Those are the brand names of Pfizer and Moderna vaccines, respectively, however they have yet to take hold with consumers, media or even medical professionals.

And there are others. Covid vaccine brand names also include AstraZeneca’s Vaxzevria, Novovax’s Nuvaxovid, and Sanofi and GlaxoSmithKline’s Vidprevtyn. J&J’s Janssen-developed Covid vaccine is the lone major holdout and is still yet to be named, if ever. In EMA filings approving its conditional use, the brand name is listed simply as ‘Covid-19 Vaccine Janssen.’

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In an effort to up its development of microbial-derived proteins, Swiss CDMO Lonza will invest in its manufacturing capacities in its home country.

The extension will be good to go by the end of this year, the company said. The expanded development will strengthen the upstream, downstream and process analytics support for new projects. The microbial footprint at its Visp site will be consolidated, and new high-throughput equipment and automation processes will be added to increase efficiency and project delivery. That will include three liquid handling workstations, and the upgrades will help improve data generation.

The FDA’s backlog of drug manufacturing facility inspections continues to be a sore spot for the agency, as FDA said Monday that a total of 52 new drug (but no biologics) applications still remain delayed due to the backlog from the pandemic.

And while the agency has maintained that it won’t issue a CRL for a delayed inspection, the number of delayed applications is rising as FDA said in May that 48 new drug applications have been delayed due to FDA’s inability to conduct pre-approval, pre-market, or pre-license inspections as of last March.

Stephen Hahn and Donald Trump, AP Images

The House Select Subcommittee on the Coronavirus Crisis on Monday questioned former FDA commissioner Stephen Hahn on whether he acquiesced to political pressure in authorizing the use of hydroxychloroquine and convalescent plasma early in the pandemic, despite limited evidence of their effectiveness.

Hahn publicly disavowed any political interference in any of his agency’s EUA decisions, but behind the scenes, the pressure clearly caught up with him.

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Paul Hudson, Sanofi CEO (Eric Piermont/AFP via Getty Images)

Back in June, Sanofi unveiled a big project to reshape its R&D around the future of mRNA, and followed that up Monday by taking a step toward achieving that goal.

The French drugmaker signed a deal with Chinese tech giant Baidu to access its AI algorithm for mRNA-based therapeutics, Baidu said Monday morning. It’s for an undisclosed sum, but Baidu noted its platforms will be used to ‘contribute to the optimization of mRNA sequences’ in Sanofi’s drug development processes.

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