A treatment developed by BridgeBio for an increasingly common heart disease missed its primary endpoint in a closely watched trial, the company said Monday, derailing its plans and prolonging the development of what experts considered a promising new drug.
Patients treated with the drug, called acoramidis, performed no better than those on a placebo on a test of how far they could walk over the course of six minutes. BridgeBio enrolled about 600 patients with ATTR-CM, a progressive heart disease. After 12 months, patients who got acoramidis could walk nine meters fewer, and patients on placebo walked seven meters fewer. Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. What’s included? Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. This name will appear with your comment
https://www.statnews.com/2021/12/27/in-a-baffling-disappointment-bridgebios-heart-drug-misses-primary-goal-in-pivotal-study/
