M. Madan Babu’s Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biology is seeking a highly driven, full-time Principal Bioinformatics Research Scientist to serve as a Database Engineer to support the Kalodimos and Babu Groups on the Blue Sky Initiative “Seeing the Invisible in Protein Kinases.” This project is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027 (pp 62-63). This is a joint project between the Kalodimos Lab and the Babu Group at St Jude.
The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.
This position is for a senior-level database engineer who will employ a variety of languages and tools to develop, construct, test and maintain data pipelines to organize multimodal biological information, and work with data scientists and visualization specialists to make biological discoveries and reveal fundamental principles of biological systems. The ideal candidate will have strong experience working in data warehouse environments and developing data marts to help scientists query, visualize and understand high-dimensional biological data. This role requires a strong background in computer science, data architecture and database management. You will work with an interdisciplinary team of 40 scientists including biochemists, spectroscopists, data scientists and bioinformaticians; exceptional communication (written and verbal), training experience and critical thinking skills are a must. When submitting your application, please include your CV and a cover letter. St Jude offers a well-defined career ladder with potential for growth and advancement. Industry-competitive salaries are based on your degree and years of experience.
Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children’s Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.
The Department of Structural Biology is building one of the world’s most comprehensive research center for defining molecular structures to understand health and disease at the molecular level. The Department is home to multiple Technology Core Centers (Cryo-EM and Tomography, X-ray, NMR, Single-Molecule Imaging, and Protein Technologies) ready to characterize Data Driven Discoveries.
St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s ‘Best Places to Work,’ as well as ‘Best Workplace for Women’ and ‘Best Workplace for Diversity.’ We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Kalodimos and Babu Groups strive to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
https://www.nature.com/naturecareers/job/database-engineer-principalsenior-bioinformatics-research-scientist-st-jude-childrens-research-hospital-st-jude-749030
